FOOTNOTES:
[1] Versus predecessor device Aeroneb Go.
[2] Using 2.5ml salbutamol
[3] Asthma.org.uk. Advice/inhalers medicines_treatments/inhalers-and-spacers. Accessed January, 2016
[4] Gardenhire D., Arzu A., Dean H., Myers T. A guide to aerosol delivery devices for respiratory therapists 3rd edition, American Association for Respiratory Care, 2013.
[5] Salzman G., Pyszynski D. Oropharyngeal candidiasis in patients treated with beclomethasone dipropionate delivered by metered-dose inhaler along and with Aerochamber. Journal of Allergy and Clinical Immunology, 1988; Volume 81, Issue 2: 424-428.
[6] Derendorf H., Nave R., Drollmann A., Cerasoli F., Wurst W. Relevance of pharmacokinetics and pharmacodynamics of inhaled corticosteroids to asthma. European Respiratory Journal, 2006; 28:1042-1050.
[7] Roller M., Zhang G., Troedson R.G., Leach C.L., Le Souëf P.N., Devadason S.G. Spacer inhaler technique and deposition of extra fine aerosol in asthmatic children. European Respiratory Journal, 2007; 29:299-306.
[8] Von Hollen D., Slater L., Hatley RHM. Impact of flow rate on NGI throat deposition from 3 HFA Inhaler formulations with anti-static valved holding chambers. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2013; 26(2); A45-A46.
[9] Oliveira R. F., et al. VHC performance evaluation at constant flow: 30L/min. Proceedings of the ASME2015 International Mechanical Engineering Congress and Exposition, 2015 Houston Texas.
[10] Leach C., Colice G. A Pilot Study to Assess Lung Deposition of HFA-Beclomethasone and CFC-Beclomethasone from a pressurized Metered Dose Inhaler with and without add-on spacers and using varying breath hold times. Journal of Aerosol Medicine and Pulmonary Drug Delivery, 2010; 23(6):355-361.
[11] Dickens G., et al. Pharmacokinetics of flunisolide administered via metered dose inhaler with and without a spacer device and following oral administration. Annals of Allergy, Asthma & Immunology, 2000; Volume 84, 528-532.
[12] Asthma.org.uk. All_about_asthma/controlling_your_asthma/resources_to_help_you/peak_flow_diary. Accessed January, 2016
[13] Tong, K. et al. An Instrumented Valved Holding Chamber with facemask to measure application forces and flow in young asthmatic children. Journal of Aerosol Med and Pulm Drug Del. 2014; 27 (Suppl 1): S55-62.